Epidermolytic hyperkeratosis

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

epidermolytic hyperkeratosis (e); Hyperkeratosis epidermolytic

Definition
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Dermatohistopathological reaction pattern of the epidermis characterized by hyperkeratosis with orthokeratosis, hypergranulosis and cytolysis in the upper layers of the stratum spinosum and stratum granulosum. The basal epithelial cells show a granular eosinophilic degeneration with bright cytoplasm and clumped keratohyalin granules. Electron microscopy reveals suprabasal keratinocytes with irregularly aggregated intermediate keratin filaments.

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Last updated on: 29.10.2020

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