Doxorubicin, liposomal
Definition
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Liposomal encapsulated doxorubicin.
Indication
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AIDS-associated Kaposi sarcoma with low CD4 values (< 200 CD4 lymphocytes/ml) and extensive mucocutaneous and visceral involvement.
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Pregnancy/nursing period
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Do not use during pregnancy or breastfeeding (serious side effects on breastfed children)!
Dosage and method of use
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AIDS-associated Kaposi sarcomas: 20 mg/m2 KO in 250 ml 5% glucose for infusion i.v., every 2-3 weeks, for 2-3 months Continue treatment as long as necessary to maintain therapeutic success.
Contraindication
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Do not use on AIDS-associated Kaposi sarcomas that can be successfully treated with local therapy or systemic interferon alpha therapy.
Preparations
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Caelyx
Note(s)
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The efficacy of pegylated liposomal doxorubicin for the treatment of mycosis fungoides has been described in several studies. The effectiveness of the therapy is still controversially discussed; in 2000, Wollina et al. reported a clinical response of 83% in a case report with 6 patients. Similarly good results were also published in subsequent studies. However, the significance of these studies is limited by the small number of subjects.
Literature
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- Wollina U et al (2000) Treatment of relapsing or recalcitrant cutaneous T-cell lymphoma with pegylated liposomal doxorubicin. J Am Acad Dermatol 42: 40-46
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Prof. Dr. med. Peter Altmeyer