Diethylcarbamazine

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

DEC

Definition
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Half-life
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9–13 h

Pharmacodynamics (Effect)
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Immobilization and inhibition of muscle activity.

Spectrum of action
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Filaria (Brugia malayi, Loa loa, Onchocerca volvulus and Wucheria bancrofti), Larva migrans by Toxocara spp.

Indication
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Dosage and method of use
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  • Brugia malayii: 3 times 2 mg/kg bw/day p.o. for 3-4 weeks.
  • Brugia timori: 3 times 5 mg/kg bw/day for 2-3 weeks.
  • Loa loa: 3 times 2 mg/kg bw/day for 3-4 weeks or 50 mg on day 1; 2 times 50 mg on day 2; 3 times 50 mg on day 3; 2 times 100 mg on day 4; 3 times 100 mg on day 5.
  • Mansonella ozzardi: 3 times 6 mg/kg bw/day for 10 days.
  • Onchocerca volvulus: 50 mg on day 1; 100 mg on day 2; 200 mg on day 3; 2 times 200 mg on day 4; 3 times 200 mg on day 5-12.
  • Toxocara spp.: 3 times 2 mg/kg bw/day for 4 weeks.
  • Wucheria bancrofti: 3 times 2 mg/kg bw/day for 3-4 weeks.

Notice! The often quite violent reactions in case of onchocerciasis (mazzotti reaction with danger of blindness) can be intercepted by administration of dexamethasone. Before therapy of onchocerciasis, a stronger eye infestation should be excluded!

Undesirable effects
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Allergic reactions, nausea, fever, headaches, tremor, vision and balance problems, ataxia.

Notice. The death of the parasites or larvae stages results in the release of allergens, which can cause severe allergic reactions!

Contraindication
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Epilepsy, renal insufficiency.

Preparations
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Hetrazan; Banocide (both preparations are not approved in Germany and are available from international pharmacies)

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Last updated on: 29.10.2020