Dexpanthenol

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

INCI designation: Panthenol; Panthenol; Provitamin B5

Definition
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Alcohol of pantothenic acid which is a component of coenzyme A.

Indication
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Systemically e.g. in alopecia areata, externally in inflammation of mucous membranes or superficial wounds (promotion of epithelialisation), dermatitis solaris.

Dosage and method of use
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  • Systemic: 500-1000 mg/day i.v. or i.m. over 14 days, repeated at monthly intervals if necessary.
  • Topical: Apply a thin layer 1-3 times/day to the affected skin areas.

Standard concentration
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5% in creams, ointments, lotions, solutions, eye drops or ointments.

Undesirable effects
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In case of systemic administration: bronchial asthma, angioedema, anaphylactic reactions. Contact allergies with topical application.

Interactions
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In combination with antibiotics, barbiturates and narcotics: intensification of allergic reactions.

Contraindication
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Hypersensitivity to the active substance.

Preparations
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Bepanthene, dexpanthenol; Bepanthene antiseptic cream (combination with chlorhexidine)

Note(s)
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Dexpanthenol may also be included in multivitamin tablets.

Literature
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  1. Röckmann H et al (2005) Anaphylaxis after dexpanthenol exposure by multivitamin tablets. Clin Exp Dermatol 30: 714-716

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Last updated on: 29.10.2020