Dexpanthenol
Synonym(s)
INCI designation: Panthenol; Panthenol; Provitamin B5
Definition
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Alcohol of pantothenic acid which is a component of coenzyme A.
Indication
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Systemically e.g. in alopecia areata, externally in inflammation of mucous membranes or superficial wounds (promotion of epithelialisation), dermatitis solaris.
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Dosage and method of use
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- Systemic: 500-1000 mg/day i.v. or i.m. over 14 days, repeated at monthly intervals if necessary.
- Topical: Apply a thin layer 1-3 times/day to the affected skin areas.
Standard concentration
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5% in creams, ointments, lotions, solutions, eye drops or ointments.
Undesirable effects
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In case of systemic administration: bronchial asthma, angioedema, anaphylactic reactions. Contact allergies with topical application.
Interactions
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In combination with antibiotics, barbiturates and narcotics: intensification of allergic reactions.
Contraindication
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Hypersensitivity to the active substance.
Preparations
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Bepanthene, dexpanthenol; Bepanthene antiseptic cream (combination with chlorhexidine)
Note(s)
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Dexpanthenol may also be included in multivitamin tablets.
Literature
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- Röckmann H et al (2005) Anaphylaxis after dexpanthenol exposure by multivitamin tablets. Clin Exp Dermatol 30: 714-716
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Prof. Dr. med. Peter Altmeyer