DefinitionThis section has been translated automatically.
Antiretrovirally active substance for the inhibition of the viral HIV protease( protease inhibitor).
IndicationThis section has been translated automatically.
Antiretroviral therapy of human immunodeficiency virus (HIV-1) infections in multi-treated adults who have failed under more than one treatment regimen with a protease inhibitor.
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Pregnancy/nursing periodThis section has been translated automatically.
Basically contraindicated! Use in pregnant women only under strict benefit/risk assessment. Do not use in nursing HIV-infected mothers, as it is not known whether the preparation passes into breast milk.
Dosage and method of useThis section has been translated automatically.
Prezista: 2 times/day 600 mg p.o., each time in combination with 100 mg ritonavir (to boost the effect) and together with a meal (improved absorption).
Undesirable effectsThis section has been translated automatically.
Mostly mild gastrointestinal side effects (diarrhoea), minor dyslipidemia and liver elevation.
InteractionsThis section has been translated automatically.
Do not use together with St. John's wort, echinacea, rifampicin, rifapentin, phenobarbital, phenytoin, carbamazepine, ergotamine preparations, and other protein inhibitors (except atazanavir and indinavir).
Remember! Important exception compared to other protease inhibitors: concomitant use of pravastatin is contraindicated; in hypercholesterolaemia, the lowest possible dose of atorvastatin (10 mg) should be used for treatment.
ContraindicationThis section has been translated automatically.
- Allergies (hypersensitivity) to darunavir or other components of the drug.
- Patients with severe liver dysfunction (Child-Pugh class C).
- e.g. ergometrin, ergotamine, methylergometrin], substances to increase gastrointestinal motility [cisapride], certain neuroleptics [pimozide, sertindole], certain sleeping pills [triazolam, midazolam], certain cholesterol-lowering drugs [simvastatin and lovastatin, pravastatin].
PreparationsThis section has been translated automatically.
Prezista
Prof. Dr. med. Peter Altmeyer