Remember! Before starting therapy, during therapy and up to one month after discontinuing the preparation, pregnancy must be ruled out in women of childbearing age and effective contraception must be exercised!

Undesirable effects
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Major side effects are acne vulgaris, weight gain, libido changes, virilisation, irregular menstrual bleeding, deepening of the voice (in contrast to the other side effects, this is not reversible; patients must be informed about this)!

Interactions
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See Table 1.

Contraindication
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Pregnancy, lactation, singing (voice deepening), severe liver disease, thromboembolic diseases, androgen-dependent tumors, hyperlipoproteinemia, hypercalcemia, hypercalzuria, breast or prostate cancer in the medical history.

Preparations
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Danadrol (available through the international pharmacy)

Note(s)
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Until 2006, the active ingredient was approved in the Federal Republic of Germany for various indications, including as a contraceptive, for the treatment of endometriosis and hereditary angioedema, for the treatment of cycle disorders and lumps in the breast. After 2006 the approval in the FRG/EU expired. However, the active ingredient is available through international pharmacies as an imported drug.

Notice! Due to its status as an imported drug, the health insurance company must clarify any cost transfer before starting treatment for angioedema.

Tables
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Main interactions of Danazol

Antidiabetics, oral	Carbohydrate tolerance changed
Anticoagulants, oral	Anticoagulant effect ↑
Carbamazepine	Carbamazepine effect ↑
Insulin	Hypoglycaemia
Contraceptives, oral	Anabolic effect ↓