Colistin
Synonym(s)
Colistin sulphate
Definition
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Narrow spectrum antibiotic (polypeptide antibiotic).
Spectrum of action
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Bactericide against Gram-negative bacteria (P. aeruginosa, E. coli, H. influenzae, Salmonella, Shigella).
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Indication
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Selective intestinal decontamination according to Stoutenbeck.
Dosage and method of use
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Adults: 4 times/day 4 tr., teenagers 4 times/day 3 tr., school children (7-12 years) 4 times/day 2 tr.
Undesirable effects
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Rare allergic reactions, gastrointestinal disorders (nausea, vomiting, stomach pain, diarrhea).
Contraindication
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Premature and newborns, hypersensitivity to polymyxins, patient with damaged intestinal mucosa (Crohn's disease, ulcerative colitis)
Preparations
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Colistin