DefinitionThis section has been translated automatically.
Malignant, very invasively growing tumour of the ectodermal embryonic chordae that spreads to the skin.
ManifestationThis section has been translated automatically.
Mostly higher age.
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LocalizationThis section has been translated automatically.
Mainly base of the skull; sacrococygeal area.
Clinical featuresThis section has been translated automatically.
Uncharacteristic pain, neurological deficits, destruction of the surrounding bone tissue. In case of skin invasion (per continuitatem), rough, bumpy, subcutaneous, later ulcerating nodules.
HistologyThis section has been translated automatically.
Detection of chondroid and dedifferentiated cells with variable presence of large, polygonal, vacuolated, plant leaf-like cells in myxoid matrix. These stain positive for S100, keratin, EMA, vimentin and the transcription factor T .
TherapyThis section has been translated automatically.
Excision in healthy individuals, possibly in combination with radiation therapy or cytostatics by radiologists and oncologists.
LiteratureThis section has been translated automatically.
- Rich TA et al (1985) Clinical and pathologic review of 48 cases of chordoma. Cancer 56: 182-187
- Su WP et al (1993) Chordoma cutis: a report of nineteen patients with cutaeous involvement of chordoma. Am J Acad Dermatol. 29: 63-66
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Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer