Cholesterol, extracellular - Altmeyers Encyclopedia

History
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Urbach, 1967

Definition
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Erythema elevatum diutinum with secondary lipid deposits in the connective tissue (see Wolff HH et al. 1978; see also further discussion under Erythema elevatum diutinum).

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Dermatology

Erythema elevatum diutinum

Relatively rare (less than 1000 cases have been described in the literature worldwide), benign, albeit emin...

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Manifestation
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Later in life.

Localization
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Extremities, face, neck and buttocks.

Clinical features
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Relapsing, brownish to livid, coarse confluent nodules and infiltrated plaques with a yellowish center. Additionally, facultative efflorescences corresponding to erythema elevatum diutinum with yellowish-brownish hue, in the dependent areas brownish-purple. Reported in association with these skin lesions were hepatosplenomegaly, diffuse or nodular compaction in the area of the lungs.

Histology
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Leucocytoclastic vasculitis, dense mixed cell infiltrate, extracellular cholesterol deposition.

Therapy
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Corresponding to the erythema elevatum diutinum. If necessary experiment with laser treatment(argon,_{CO2 laser}) or electrocautery. See also Xanthelasma.

Progression/forecast
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Chronic, intermittent course, healing of the skin changes with hyperpigmentation or scarring.

Literature
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Urbach E, Epstein E, Lorenz K (1967) Extracellular cholesterolosis. Arch Dermatol Syphil (Berlin) 166: 243-272.
Wolff HH et al (1978) Erythema elevatum diutinum. I. Electron microscopy of a case with extracellular cholesterinosis. Arch Dermatol Res 15:261:7-16.