Cefepim

Definition
This section has been translated automatically.

β-Lactamase-resistant broad spectrum cephalosporin of the 4th generation. Cefepim is the most stable cephalosporin compared to β-lactamases.

Half-life
This section has been translated automatically.

2 h

You might also be interested in

Dermatology

Nevus melanocytic common: Copoun-type melanocytic nevus existingsince early childhood.

Naevus melanocytic common

Benign, congenital or acquired, melanocyte-derived, brown to brown-black, rarely reddish or skin-colored, p...

Advertisment

Spectrum of action
This section has been translated automatically.

Acinetobacter spp., Citrobacter spp., Enterobacter spp., E. coli, Hafnia alvei, Haemophilus spp., Klebsiella spp., Moraxella catarrhalis, Morganella morganii, Neisseria spp, Proteus spp., Providencia spp., Pseudomonas spp., Salmonella spp., Serratia spp., Shigella spp., Staphylococcus spp., Streptococcus spp.

Indication
This section has been translated automatically.

Severe, life-threatening respiratory and bile duct infections.

Dosage and method of use
This section has been translated automatically.

2 times/day 2 g slowly i.v. or as a short infusion, in immunocompromised patients 3 times 2 g/day. Treatment duration: 7-10 days, max. 14 days.

Undesirable effects
This section has been translated automatically.

Neurotoxicity (Payne LE et al. 2017)

Preparations
This section has been translated automatically.

Maxipime®

Literature
This section has been translated automatically.

Payne LE et al (2017) Cefepime-induced neurotoxicity: a systematic review. Crit Care 21:276.
Lacroix C et al (2019) Serious central nervous system side effects of cephalosporins: A national analysis of serious reports registered in the French Pharmacovigilance Database.J Neurol Sci 398:196-201.
Mullins BP et al (2018) Comparison of the Nephrotoxicity of Vancomycin in Combination With Cefepime, Meropenem, or Piperacillin/Tazobactam: A Prospective, Multicenter Study. Ann Pharmacother 52:639-644.