Cd134

CD134/TNFRSF4 (TNFRSF4 stands for "TNF Receptor Superfamily Member 4") is a member of the TNF receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with the adaptor proteins TRAF2 and TRAF5.

Immunohistochemical Data:

• Marks activated CD4+ cells, virally stimulated CD4+ cells (high expression).
• Structure: Transmembrane glycoprotein (35 kDa).
• Application: FACS, IHC (G)

CD 134 belongs to the tumor necrosis factors. CD 134 is jointly responsible for the clonal expansion of CD4+ cells and for the formation of memory T cells. CD 134 also seems to be involved in T-cell adhesion processes.

1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.