Cd128

CD128 (CD stands for "cluster of differentiation") also CXCR1 (CXC-motif chemokine receptor 1) or interleukin-8-receptor alpha (IL-8RA) is a protein receptor that is expressed on the surface of neutrophilic granulocytes and macrophages.

Cytokines like interleukin 8 or CXCL6 (GCP-2) bind to the protein. This binding activates an intracellular signal transduction cascade, which leads to an increase in intracellular calcium concentration and in which G-proteins and MAP kinases are involved.

Interleukin-8 itself plays an important role in the initiation and maintenance of inflammatory and tumorous diseases (see Interleukin-8).