Synonym(s)
CDw121b; IL1R2; IL-1R-2; IL1R2c; IL1RB; IL-1RT2; IL-1RT-2; interleukin 1 receptor type 2; Interleukin-1 receptor type 2; Interleukin 1 receptor type II
DefinitionThis section has been translated automatically.
CD121b (Cluster of Differentiation 121b), is a 60 kDa cytokine receptor, also known as interleukin-1 receptor type 2 (IL-1R2), a ligand for interleukin-1.
The coding gene is located on chromosome 2q12. The IL-1R2 protein interacts "non-productively" with interleukin-1 and thus plays a role as a suppressor of IL-1 activity.
LiteratureThis section has been translated automatically.
- Lang, D et al (1998). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness." Journal of Immunology 161: 6871-6877.
- Wang D et al (2010) Structural insights into the assembly and activation of IL-1β with its receptors. Nature Immunology 11: 905-911.
Prof. Dr. med. Peter Altmeyer