CCL27 gene

The CCL27 gene (CCL27 stands for: C-C Motif Chemokine Ligand 27) is a protein coding gene located on chromosome 9p13.3.

This gene is a member of a CC cytokine gene cluster grouped on the p arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines.

The CCL27 chemokine encoded by this gene is chemotactic for skin-associated memory T lymphocytes. CCL27- cytokine may also play a role in lymphocyte docking in the skin. CCL27 has been shown to be expressed by TNF-alpha, interleukin-1beta in basal keratinocytes. CCL27 binds specifically to chemokine receptor 10 (CCR10). The CCR10 receptor is expressed by lymphocytes in psoriasis. Studies on a similar mouse protein suggest that these protein-receptor interactions may play a central role in T cell-mediated skin inflammation. The extent to which CCL27 is useful as a molecular marker for Dfifferencing palmar psoriasis and hadeczema remains to be seen (Technau-Hafsi K et al. 2023).

1. Garzorz N et al. (2015) NOS2 and CCL27: clinical implications for psoriasis and eczema diagnosis and management. Expert Rev Clin Immunol 11:167-169.
2. Garzorz-Stark N et al (2016) A novel molecular disease classifier for psoriasis and eczema. Exp Dermatol 25:767-774.
3. Technau-Hafsi K et al (2023) Molecular diagnostics of hand eczema. Dermatology (Heidelb) 74:410-415.