Caveolae-induced Endocytosis

Last updated on: 16.02.2021

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General information
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The original model of the plasma membrane, in which it was assumed that the membrane-building lipids and proteins are homogeneously distributed within the membrane, has been modified in recent years. It has been shown that transient areas can form within the membrane where reduced fluidity prevails due to a higher proportion of glycosphingolipids, cholesterol and GPI (glycosylphosphatidylinositol, e.g. GM1)-anchored proteins (Simons K et al. 1997). Because of their restricted lateral mobility within these microdomains, they are referred to as lipid rafts.

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The transport into the cell bypassing the lysosomal compartments makes this uptake mechanism particularly interesting for the rational development of new drug delivery systems (Bathori et al. 2004). Knowledge of the transport pathways of internalized substances is therefore the first step for this development.

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  1. Bathori G et al (2004). Caveolae-an alternative endocytotic pathway for targeted drug delivery. Crit Rev Ther Drug Carrier Syst 21: 67-95.
  2. Huth E (2005) Cellular uptake and intracellular fate of particulate drug delivery systems. Inaugural dissertation for the award of the doctorate of the Faculty of Chemistry, Pharmacy and Geosciences of the Albert-Ludwigs-University Freiburg.
  3. Mineo C et al (2001). Potocytosis. Robert Feulgen Lecture. Histochem Cell Biol 116: 109-118.
  4. Ohkuma S (1981). Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages. J Cell Biol 90: 665-669.
  5. Simons K et al (1997). Functional rafts in cell membranes. Nature 434: 569-572.

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Clathrin-coated vesicles;

Last updated on: 16.02.2021