HistoryThis section has been translated automatically.
Lauren Vedder Ackerman, 1948
DefinitionThis section has been translated automatically.
Term for a group of low-malignant, slowly exophytic, wart-like, highly differentiated spinocellular carcinomas with only a very low tendency to metastasize. The tumours originally described by Ackerman were all located in the oral cavity.
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ClassificationThis section has been translated automatically.
The following clinical pictures are regarded as variants of Carcinoma verrucosum, which differ in their localisation, but show a similar histological picture and biological growth behaviour:
- Papillomatosis cutis carcinoides (= carcinoma verrucosum of the skin)
- Florid oral papillomatosis (= carcinoma verrucosum of the oral cavity)
- Condylomata gigantea (= carcinoma verrucosum of the genital region)
- Carcinoma cuniculatum (= carcinoma verrucosum of the sole of the foot)
Other localizations are also possible, but more rarely (e.g. back, face, acral finger region, lower leg, on the floor of a chronic leg ulcer).
EtiopathogenesisThis section has been translated automatically.
- There is a discussion about the causation of genital manifestations by HPV 16.
- Oral manifestations are favoured by previous inflammatory diseases of the oral mucosa(e.g. lichen planus mucosae) and chronic "irritants", especially:
- Chewing tobacco consumption
- Betel nut chewing ( oral submucous fibrosis)
- Cath-chewing (Somalia and Yemen).
- In tropical countries the occurrence in combination with schistosomiasis has often been described.
HistologyThis section has been translated automatically.
TherapyThis section has been translated automatically.
Progression/forecastThis section has been translated automatically.
Note(s)This section has been translated automatically.
LiteratureThis section has been translated automatically.
- Ackerman LV (1948) Verrucous carcinoma of oral cavity. Surgery 23: 670-678
- Heinzerling LM et al (2003) treatment of verrucous carcinoma with imiquimod and CO2 laser ablation. Dermatology 207: 119-122
- Ho J et al (2000) An ulcerating verrucous plaque on the foot. Verrucous carcinoma (epithelioma cuniculatum). Arch Dermatol 136: 547-548, 550-551
- Lu S et al (2000) Anal verrucous carcinoma and penile condylomata acuminata. Dermatology 200: 320-323
- Matoso A et al (2012) Verrucous carcinoma of the nail unit. At the JDermatopathol
- Mehta RK et al (2000) Treatment of verrucous carcinoma of vulva with acitretin. Br J Dermatol 142: 1195-1198
- Pleat J et al (2001) Cutaneous verrucous carcinoma. Br J Plast Surgery 54: 554-555
- Already MP et al (2000) Presternal verrucous carcinoma. dermatologist 51: 766-769
- Schwartz RA (1995) Verrucous carcinoma of the skin and mucosa. J Am Acad Dermatol 32: 1-21
Terada T (2011) Verrucous carcinoma of the skin: a report on 5 Japanese cases. AnnDiagn
Incoming links (14)Ackerman, lauren-vedder; Ackerman tumor; Betel nut; Betel nut; Betel nut; Carcinoma verrucosum; Catha edulis; Gigantean condyloma; Lichen simplex chronicus verrucosus; Microscopically controlled surgery; ... Show all
Outgoing links (10)Betel nut; Bilharzia; Carcinoma cuniculatum; Catha edulis; Fibrosis oral submucous; Gigantean condyloma; Lichen planus mucosae; Papillomatosis cutis carcinoides; Papillomatosis floride oral; Squamous cell carcinoma of the skin;
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.