Carcinoma spinocellular small cell - Altmeyers Encyclopedia

Synonym(s)

Small cell carcinoma

Definition
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Apparently very rare in the skin, more common in other organs (bladder, prostate, larynx, kidney, oropharynx, etc.), histological variant of spinocellular carcinoma with a specific histological pattern.

Histology
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Monomorphic tumour parenchyma consisting of small tumour cells reminiscent of a Merkel cell carcinoma. Focal keratinization. The cells themselves are relatively rich in cytoplasm. Numerous mitoses.

Literature
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Aydin A et al (2003) Cutaneous undifferentiated small (Merkel) cell carcinoma, that developed synchronously with multiple actinic keratoses, squamous cell carcinomas and basal cell carcinoma. J Dermatol 30: 241-244
Lo Re G et al (1994) Extrapulmonary small cell carcinoma: a single-institution experience and review of the literature. Ann Oncol 5: 909-913