Capnocytophaga infection A49.9

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Infections caused by Capnocytophaga spp., especially bacterial periodontitis, abscesses in the ENT area and lung infections.

Pathogen
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  • Capnocytophaga spp. are gram-negative rods that can grow in anaerobic but also in microaerophilic (capnophilic) environments, i.e. environmentsrich in CO2. They are therefore not obligatory anaerobic. Capnocytophaga spp. are morphologically similar to Fusobacteria.
  • C. gingivalis, C. granulosa, C. haemolytica, C. ochracea and C. sputigena belong to the normal human pharyngeal flora. The human species are therefore only important as opportunistic pathogens.
  • C. canimorsus and C. cynodegmi colonize the mouth and throat of dogs and cats.

Manifestation
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In immunocompromised patients.

Clinical features
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  • Juvenile periodontitis: C. gingivalis and C. ochracea.
  • Adult periodontitis: C. sputigena.
  • Capnocytophaga spp. occasionally cause localized inflammation, e.g. abscesses in the ENT area, especially in immunocompromised patients.
  • In immunocompromised patients sepsis, peritonitis and osteomyelitis are possible.
  • C. canimorsus and cynodegmi can be isolated from wound infections after animal bites. C. cynodegmi causes localised infections, while C. canimorsus tends to cause systemic infections.

Diagnosis
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Detection by culture, RFLP.

Therapy
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  • For local infections: surgical excision.
  • For systemic infections: broad spectrum cephalosporins (e.g. cefotaxime), carbapenems (e.g. imipenem/cilastatin), gyrase inhibitors (e.g. ciprofloxacin), macrolides (e.g. clindamycin). Resistance to aminoglycosides, trimethoprim, aztreonam and metronidazole is known.

Literature
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  1. Conrads G, Mutters R, Seyfarth I, Fur K (1998) DNA-probes for the differences of Capnocytophaga species. Mol Probes 11: 323-328
  2. Williams BLC, Hammond BF (1979) Capnocytophaga: new genus of gramnegative gliding bacteria. IV. DNA basecomposition and sequence homology. Arch Microbiol 122: 29-33

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020