Blueberry muffin baby P61.8

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Synonym(s)

Cutaneous extramedullary haematopoiesis; Torch Syndrome; TORCH syndrome

Definition
This section has been translated automatically.

The term "blueberry muffin" refers to skin changes that are often characterized by blueberry-like efflorescences shimmering through the skin. It is a transient cutaneous extramedullary haematopoiesis occurring exclusively in the neonatal period as a result of a serious underlying disease which leads to the temporary reactivation of embryonic or fetal haematopoietic mechanisms after birth.

TORCH is the acronym for the following pathogens: Toxoplasma gondii, Other (Treponema pallidum, Hepatitis B, Zoster), Rubella virus, (C)ytomegalovirus, Herpes simplex virus.

Etiopathogenesis
This section has been translated automatically.

Fetal infectious diseases or diseases of the mother during pregnancy(toxoplasmosis, rubella, herpes, zoster, cytomegaly), haematolytic diseases of the fetus and resulting anaemia and neoplasia are described.

Manifestation
This section has been translated automatically.

Postnatal or in the neonatal period.

Localization
This section has been translated automatically.

Trunk, face, extremities, palmae, plantae.

Clinical features
This section has been translated automatically.

During birth or shortly after birth (especially 24-48 hours post partum) suddenly petechiae, disseminated or densely standing red to reddish-brown spots, papules and plaques; blueberry-coloured or reddish ecchymoses develop. Often acrocyanosis.

Laboratory
This section has been translated automatically.

Left shift in the differential blood count.

Histology
This section has been translated automatically.

Edematous loosening of the perivascular and periadnexial spaces of the middle or deep dermis. Often infiltrates of different neoplastic proliferations or immature cells of erythropoiesis, granulopoiesis or thrombocytopoiesis.

Diagnosis
This section has been translated automatically.

Clinic, histology, differential blood count, pathogen detection if necessary.

Therapy
This section has been translated automatically.

Treatment of the underlying disease. Spontaneous regression of the efflorescences.

Internal therapy
This section has been translated automatically.

Red cell concentrates if necessary.

Literature
This section has been translated automatically.

  1. Bowden JB et al (1989) Dermal hematopoiesis in neonates: report of five cases. J Am Acad Dermatol 20: 1104-1110
  2. Hodl S et al (2001) Blueberry muffin baby: the pathogenesis of cutaneous extramedullary hematopoiesis 52: 1035-1042
  3. Kitagawa N et al (1989) Congenital alveolar rhabdomyosarcoma presenting as a blueberry muffin baby. J Dermatol 16:409-411
  4. Meuleman V Degreef H (1995) Acute myelomonocytic leukemia with skin localizations. Dermatology 190: 346-348
  5. Vozza A et al (2003) Late onset Blueberry Muffin Syndrome following congenital rubella. J Eur Acad Dermatol Venereol 17: 204-205
  6. Weils AJ (1923) On blood formation foci in the prostate and sole of the feet of newborns and foetuses. Z Pediatrics 35: 1-9

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Authors

Last updated on: 29.10.2020