Arthus reaction

History
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Arthus and Breton, 1903

Definition
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An immune reaction in which a severe, possibly necrotizing inflammation occurs in a sensitized organism after renewed local application of the antigen at the injection site. The formation of immune complexes leads to complement activation and leukocyte chemotaxis.

Etiology
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Type III allergy.

Literature
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Arthus M, Breton M (1903) Lesions cutanees produites par les injections de serum de cheval chex le lapin anaphylactise par et pour ce seru. Compt rend soc de Biol 55: 1478-1480
Arthus NM (1903) Injections repetees de serum de cheval chez la lapin. CR Soc Biol (Paris) 55: 817-820