Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Medicines against excessive perspiration (see below hyperhidrosis), such as aluminium compounds, tanning agents, methenamine, parasympatholytics (e.g. atropine), allantoin.

Field of application/use
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The main applications are:

  • Metal salts: First choice agents are aluminium compounds, e.g. aluminium chloride 10-20%, which can be applied mostly as an alcoholic solution, e.g. R005 or also in hydroxycellulose gel R004. They lead to toxic damage of the acrosyringium and a blockage of the excretory duct. In case of a strong sweat flow, the antiperspirants are quickly rinsed away by the liquid flow. This can be prevented by applying a 20% aluminium chloride hexahydrate gel (NRF 11.24.) overnight (2-3 times/week). Shave the armpits before!
  • Acids: Trichloroacetic acid, in combination with aluminium compounds (e.g. Ansudor powder/emulsion) or tannic acids (e.g. Tannosynt lotio/powder), causes a denaturation of the keratin of the acrosyringium and thus closes the excretory duct.
  • Aldehydes: Glutaraldehyde or formaldehyde is formed e.g. from methenamine (e.g. antihydral ointment) in the acidic environment of sweat.Caution! Toxic side effects and contact sensitization by formalin can occur!
  • Botulinum toxin is very effective.
  • In naturopathy mainly sage and rosemary are used.


Last updated on: 29.10.2020