Angiofibroma cell-rich D23.0

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Benign fibroblastic soft tissue tumor, rarely recurring postoperatively, which occurs preferably in the genital area.

Manifestation
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Women are more frequently affected than men.

Localization
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Genital area, also extremities.

Clinical features
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Symptomless, firm, reddish or slightly bluish shimmering lumps. The tumours do not grow larger than 3.0 cm in women, but up to 25 cm in men.

Histology
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Sharply defined tumour with numerous thick-walled hyalinised vessels, abundant spindle cells and interspersed adipocytes. Mitoses can be numerous. Lipogenic differentiation is not uncommon. The tumor parenchyma often expresses CD34, alpha-smooth muscle actin and desmin, but not S-100 protein and pancytokeratin.

Literature
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  1. Ahmadnia HJ et al (2014) Angiofibroma of the vulva. Cutan Med Surg 18:203-205
  2. Mentzel T (2016) Mesenchymal tumors of the skin. In: Cerroni L et al. histopathology of the skin. Springer-Verlag Berlin Heidelberg New-York S 751-753

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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020