Ambroxol

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Mucolytic, expectorant. Significance in dermatology, especially in the context of drug exanthema.

Half-life
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3,5–4 h

Pharmacodynamics (Effect)
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Metabolite of bromhexine, secretolytic, stimulation of surfactant synthesis in type II pneumocytes, antioxidant.

Indication
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Expectoration promotion in bronchial asthma, chronic bronchitis, cough.

Limited indication
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Pregnancy 1st trimester, lactation, epilepsy, renal failure.

Dosage and method of use
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  • In the first 2-3 days of treatment 30 mg p.o. 3 times/day, then 30 mg twice/day or 15 mg 3 times/day.
  • 1-2 times/day 2-3 ml of the 0.75% solution per inhalation
  • 2-3 times/day 15-30 mg i.v., s.c. or i.m.

Undesirable effects
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Allergic reactions up to anaphylactic shock, headache, seizures, facial edema, dyspnoea, laryngeal edema, gastrointestinal disorders, arthralgias.

Interactions
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No simultaneous administration of antitussives, as there is a risk of secretion congestion.

Contraindication
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Paragroup allergy (for some liquid preparations), bronchial asthma: for sulphite-containing preparations

Preparations
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Ambroxol, Bronchopront, Mucosolvan, Pediamuc

Patientinformation
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Patients should drink a lot, as this is the basic condition for an expectorant stimulating effect!

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Last updated on: 29.10.2020