Alpha-2-antiplasmin

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

alpha-2-antiplasmin

Definition
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The alpha-2-antiplasmin is quantitatively the strongest inhibitor of fibrinolysis. It is synthesized in the liver. The alpha-2-antiplasmin has a molecular weight of 70,000 D and forms inert complexes at a ratio of 1:1 with plasmin by binding to the active site of the light chain. It is detectable in plasma and reduces the binding of plasmin to fibrin after it has been stabilized by factor XIIIa . The concentration in plasma is 0.07 g/l, the half-life is 2.6.

Literature
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  1. HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin S. 110.

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Last updated on: 29.10.2020

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