All, skin manifestations C83.5

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Acute lymphatic leukemia; lymphoblastic leukemia; lymphoblastic lymphosarcoma; malignant lymphoma with small non cleaved follicle center cells; Paramyeloblastic leukemia; Stem cell leukemia

Definition
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Lymphoma of high malignancy, which can immunologically show B (B-LBL), or T cells (T-LBL) Specific skin lesions are rare.

Manifestation
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Especially occurring in children.

Clinical features
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Solitary, but also multiple nodes of different sizes, often ulcerated.

Histology
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  • Regardless of their origin (B or T cells), the histological pattern is the same: dense, diffuse, monomorphic infiltrate in the dermis and subcutis. Sometimes starry sky pattern. Cytomorphologically, there are medium-sized or large lymphoblasts, with round or angular nuclei with irregularly distributed chromatin, usually a narrow cytoplasmic border, with large macrophages in between.
  • Immunohistology:
    • B-LBL: positive for: CD20, CD10, CD43, CD34
    • T-LBL: positive for: CD1a, CD3, CD43; negative for B-cell marker

Differential diagnosis
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Myelomonocytic leukemias; mantle cell lymphoma; Merkel cell tumor;
skin metastases of a small cell bronchial carcinoma.

Literature
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  1. Kaddu S, Cerroni L, Kerl H (2003) Leukemias of the skin. In: Kerl H et al (ed.) Histopathology of the skin. Springer publishing house, Berlin Heidelberg New York, S. 917-919

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Authors

Last updated on: 29.10.2020