Alizapride
Definition
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Antiemetic, dopamine antagonist.
Indication
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Prophylactically for cytostatic-induced vomiting, radiation damage or post-operatively.
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Limited indication
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Pregnancy, renal insufficiency.
Dosage and method of use
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For cytostatic drug therapy 150 mg p.o. before and 150 mg after cytostasis, 3 times 50 mg p.o. the following day. Alternatively 100 mg i.v. before and 100 mg i.v. or i.m. after cytostatic drug application.
Undesirable effects
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CNS disorders, dizziness, RR decline, diarrhea, dry mouth, amenorrhea.
Interactions
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Table 1.
Contraindication
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Children < 14 years, pheochromocytoma, late dyskinesia, prolactinoma.
Preparations
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Vergentan
Tables
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Key interactions of alizapride
Alimemazine |
extrapyramidal symptoms ↑ |
Anticholinergics |
mutual effect ↓ |
Alcohol |
central attenuation |
Chlorphenethazine |
extrapyramidal symptoms ↑ |
Lisurid |
Lisuride effect ↓ |
Mequitazine |
extrapyramidal symptoms ↑ |
Neuroleptics |
extrapyramidal symptoms ↑, avoid combination |
Scopolamine |
Scopolamine effect ↓ |
CNS damping agent |
central damping ↑ |
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Prof. Dr. med. Peter Altmeyer