Albendazole

Definition
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Anthelmintic.

Half-life
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1,5 h

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Pharmacodynamics (Effect)
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Inhibition of the polymerisation of the tubulin structures of the cytoskeleton with the consequence of degenerative changes in the intestine and segment of the worms.

Spectrum of action
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Ancylostoma duodenale, Ascaris lumbricoides, Enterobius vermicularis, Necator americanus, Trichuris trichiura, Echinococcus spp.

Indication
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Infections with helminths in trichinosis, strongyloidosis, larva migrans, filariasis (loiasis).
Inoperable or not radically operable forms of infections with Echinococcus cysticus (dog tapeworm) and Echinococcus alveolaris (fox tapeworm) for preoperative support of surgical therapy.

Limited indication
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Children < 6 years.

Dosage and method of use
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See Table 1.

Note! In women of childbearing age: Effective anticonceptive treatment (ovulation inhibitors are not sufficient!) before, during and one month after therapy!

Undesirable effects
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During the first days of treatment: fever and/or nosebleed, pruritus, exanthema, hair loss, dizziness, headache, gastrointestinal problems, transaminase increases, leucopenia, pancytopenia, aspermia.

Notice! Check liver values and BB before each treatment, after 5 and 10 days, then every 14 days. Stop treatment if the values increase more than twice the norm!

Contraindication
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Pregnancy, lactation, children < 3 years.

Preparations
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Eskazole

Patientinformation
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Taking tablets with a fatty diet!

Tables
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Dosage of Albendazole

Indication	Dosage
Ancylostoma brazilse	400 mg/day p.o. over 2 days
duodenal ancylostoma	400 mg/day p.o. as ED
angiostrongylus cantonensis	100 mg/12 hours p.o. over 8 days
Ascaris lumbricoides	400 mg/day p.o. as ED
Echinococcus cysticus	5 mg/kg bw/12 hrs over 4 weeks, repeat therapy cycle after 14-day break, not more than 3 therapy cycles in total
Echinococcus alveolaris and multilocularis	see above, but intermittent long-term therapy over months to years
larva currens	400 mg/day p.o. over 3 days
larva migrans	400 mg/day p.o. over 3 days
Necator americanus	400 mg/day p.o. as ED
trichuris trichiura	400 mg/day p.o. over 3 days
Strongyloides stercoralis	20 mg/day in 3 doses over 3 days