Adrenal gland, skin changes L81.4

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Diffuse melanodermia can occur in the context of an adrenal cortex insufficiency. S.a.u. M. Addison.

Classification
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  • Adrenocortical insufficiency:
  • Adrenocortical hyperfunction, partial function of cortisol:
    • Cushing's syndrome:
      • Central Cushing's syndrome (Cushing's disease): Increased production of ACTH in the anterior pituitary gland with subsequent increased corticoid release from the adrenal cortex (see also pituitary diseases, skin changes).
      • Adrenal Cushing's Syndrome (increased secretion of gluco- or mineralocorticoids from the adrenal cortex in the course of neoplasia (adenomas or carcinomas) with subsequent suppressed release of ACTH from the anterior pituitary gland); so-called "white Cushing's" see Addison, whiter.
      • Ectopic (paraneoplastic) Cushing's syndrome (formation of corticoids in ectopic tissue, e.g. in small cell bronchial carcinoma).
      • Iatrogenic Cushing's syndrome (after regular, systemic administration of ACTH or glucocorticoids).
      • Hypothalamic-pituitary Cushing's syndrome (disturbances in hypothalamic-pituitary regulation).
      • Pseudo-Cushing's syndrome, so-called Cushingoid (passagere Cushing's symptoms e.g. after severe cranial injuries).
  • Adrenal cortex hyperfunction, androgen partial function (dehydroepiandrosterone, androstendione):
  • Adrenal medullary hyperfunctions:

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Last updated on: 29.10.2020