Adenocarcinoma, primarily mucinous C80

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Carcinoma mucinous eccrine; Cutaneous mucinous carcinoma; Mucinous eccrine carcinoma

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Relatively rare mucinous tumor of the eccrine glands. Occasionally regional lymph node metastases, very rarely more extensive metastases. Important differential diagnosis is the metastatic mucinous adenocarcinoma, mostly from the intestine.

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Eyelids, neck, capillitium, rarely trunk, feet, vulva.

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Clinical features
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Deeply cutaneous, only slowly growing, 0.2-1.0 cm large, firm, painless lump. The clinical symptoms are not very specific, so that the histological findings are random.

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  • Irregularly arranged tumor clusters in the middle and deep dermis, in which nests or strands of epithelia are embedded in a broad mucinous stroma. The mucinous areas are often subdivided by fine bony tissue septums. More rarely, the epithelial tumor clusters come into direct contact with the surrounding connective tissue.
  • Detection of myoepithelial cells using the immune markers calponin, CK5/6 or p63.

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  1. Qureshi H et al (2004) Primary cutaneous mucinous carcinoma: Presence of myoepithelial cells as a clue to the cutaneous origin. At J Dermatopathol 26: 353-358


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Last updated on: 29.10.2020