Adenocarcinoma, primarily mucinous C80

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Carcinoma mucinous eccrine; Cutaneous mucinous carcinoma; Mucinous eccrine carcinoma

Definition
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Relatively rare mucinous tumor of the eccrine glands. Occasionally regional lymph node metastases, very rarely more extensive metastases. Important differential diagnosis is the metastatic mucinous adenocarcinoma, mostly from the intestine.

Localization
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Eyelids, neck, capillitium, rarely trunk, feet, vulva.

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Clinical features
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Deeply cutaneous, only slowly growing, 0.2-1.0 cm large, firm, painless lump. The clinical symptoms are not very specific, so that the histological findings are random.

Histology
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  • Irregularly arranged tumor clusters in the middle and deep dermis, in which nests or strands of epithelia are embedded in a broad mucinous stroma. The mucinous areas are often subdivided by fine bony tissue septums. More rarely, the epithelial tumor clusters come into direct contact with the surrounding connective tissue.
  • Detection of myoepithelial cells using the immune markers calponin, CK5/6 or p63.

Literature
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  1. Qureshi H et al (2004) Primary cutaneous mucinous carcinoma: Presence of myoepithelial cells as a clue to the cutaneous origin. At J Dermatopathol 26: 353-358

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020