Adenocarcinoma, primarily mucinous - Altmeyers Encyclopedia

Synonym(s)

Carcinoma mucinous eccrine; Cutaneous mucinous carcinoma; Mucinous eccrine carcinoma

Definition
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Relatively rare mucinous tumor of the eccrine glands. Occasionally regional lymph node metastases, very rarely more extensive metastases. Important differential diagnosis is the metastatic mucinous adenocarcinoma, mostly from the intestine.

Localization
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Eyelids, neck, capillitium, rarely trunk, feet, vulva.

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Dermatology

Elastosis actinica: extensive elastosis of the skin with telangiectasia.

Actinic elastosis

Skin change occurring in sun-exposed areas of older people, predominantly with light complexion, characteri...

Clinic
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Deeply cutaneous, only slowly growing, 0.2-1.0 cm large, firm, painless lump. The clinical symptoms are not very specific, so that the histological findings are random.

Histology
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Irregularly arranged tumor clusters in the middle and deep dermis, in which nests or strands of epithelia are embedded in a broad mucinous stroma. The mucinous areas are often subdivided by fine bony tissue septums. More rarely, the epithelial tumor clusters come into direct contact with the surrounding connective tissue.
Detection of myoepithelial cells using the immune markers calponin, CK5/6 or p63.

Literature
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Qureshi H et al (2004) Primary cutaneous mucinous carcinoma: Presence of myoepithelial cells as a clue to the cutaneous origin. At J Dermatopathol 26: 353-358