Adamts-like protein 5

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Smaller protein group (5 members have been described so far) with a large homology to the ADAMTS family of a group of zinc-containing metalloproteinases, which has 20 members so far.

The ADAMTS-like protein 5 was identified as an autoantigen produced by melanocytes. It is presented in psoriatic inflammation by the HLA major risk gene HLA-C*06:02 and can then be recognized by the T-cell receptor (TCR) Vα3S1/Vβ13S1 on Th17 cells.

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Recently, the hypothesis has come to the fore that melanocytes are target cells of an autoimmune response in psoriasis. Psoriasis as an autoimmune reaction against melanocytes of the skin . This would explain the skin-specific character of psoriasis.

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  1. Arakawa A et al (2015) Melanocyte antigen triggers autoimmunity in human psoriasis. J Exp Med 212: 2203-2212.
  2. Prince JC (2016) Autoimmune reaction in psoriasis. Dermatologist 6: 433-437

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Adamts13; Psoriasis (Übersicht);


Last updated on: 29.10.2020