Acanthoma acantholytic dyskeratotic D23.L6

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 10.03.2023

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dyskeratotic acanthoma; epidermolytic acanthoma; Epidermolytic acanthoma

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Solitary (rarely multiple), usually skin-coloured "inconspicuous", scaly, 0.3-0.5 cm large, skin-coloured horn nodule, the diagnosis of which is only verified histologically.

The growth can be calotte-shaped or papillomatous.

Occasionally, linearly arranged nodules have also been detected.

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face, trunk (45%), extremities (25%), genitals, anal region

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Sharply defined epithelial node, which is bounded laterally and sometimes in depth by normal surface epithelium, but can also penetrate the entire epithelial ligament vertically. The tumor node is overlaid by a strong orthokeratotic corneal layer, which can be crossed by parakeratotic strips. The irregular acantholysis is conspicuous, which can run through the entire tumor parenchyma. Detection of dyskeratoses and also pathological mitoses. The dermis shows an uncharacteristic lympho-histiocytic infiltrate. The mitosis rate is significantly increased focally (see figure). This phenomenon is not so much considered a real proliferation but a "degenerative polymorphism". Lympho-histiocytic infiltrate in the dermis.

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Excision if necessary.

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  2. Kazlouskaya V et ql. (2013) Solitary epidermolytic acanthoma. J Cutan catholic 40:701-707
  3. Red SV, Bhawan J (1995) Isolated dyskeratotic acanthoma. A variant of isolated epidermolytic acanthoma. On J Dermatopathol 17: 63-66
  4. Tagami H, Yamada M (1978) Seborrheic keratosis: an acantholytic variant. J Cutan catholic 5: 145-149
  5. Tan GFet al. (2014) Anogenital epidermolytic acanthomas: effective treatment of pruritus with 0.1% tacrolimus ointment. Dermatol Ther 27:113-116

  6. Thomas M et al (2010) Linear epidermolytic acanthoma of vulva: an unusual presentation. Indian J Dermatol Venereol Leprol 76:49-51


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 10.03.2023