Nonoxinol 9

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

CAS number: 26571-11-9; Nonaethylene glycol mono(nonylphenyl) ether; nonoxynol 9

Definition
This section has been translated automatically.

Nonoxinol 9 is a non-ionic surfactant from the group of nonylphenol ethoxylates. It is used as an active ingredient in locally applied contraceptives because of its spermicidal effect. Nonoxinol is a clear, colourless to light yellow, viscous liquid.

Field of application/use
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Spermicidal action: Nonoxinol-9 attacks the membrane of the sperm. If the membrane is destroyed, the sperm are immobilized. Nonoxinol-9 is contained in many creams, gels, contraceptive suppositories and foams.


Antiviral effect: Laboratory tests have shown that nonoxinol-9 also attacks the membrane of the HIV virus; on the other hand, a vaginal wall attacked by nonoxinol-9 is also much more permeable to all types of viruses, so that there is practically no protection against viruses.

Undesirable effects
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Frequent use leads to local irritation of the vaginal mucosa. Nonoxinol-9 may increase the infectiousness for sexually transmitted diseases if used frequently. There is also statistical evidence of a link between nonoxinol-9 use and urinary tract infections. Allergic reactions also occur in rare cases.

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Last updated on: 29.10.2020