Summation anaphylaxis T78.0

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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cumulative anaphylaxis

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Form of anaphylaxis in which patients only react with anaphylactic symptoms when a combination of various co-factors, e.g. effort, medication or stress, coincide with certain otherwise tolerated foods (see below food-dependent effort induced anaphylaxis). In rare cases, anaphylaxis only occurs when 2 different co-factors interact, e.g. sport and infection, infection and medication.

Clinical features
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The prototype of a summation anaphylaxis is the"food-dependent exertion-induced anaphylaxis". Alpha-galactose syndrome is also considered to be summation anaphylaxis.

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Therapeutically, in addition to the prescription of an adrenaline autoinjector for emergency medication, the focus is always on the elimination of food allergens.

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  1. Field path AM et al (2015) Exercise-induced anaphylaxis. Immunol Allergy Clin North Am 35:261-275.

  2. Hotta A et al. (2016) Case of food-dependent exercise-induced anaphylaxis due to peach with Pru p 7 sensitization. J Dermatol 43: 222-223.

  3. Roberts H et al (2015) Food-dependent exercise-induced anaphylaxis due to chickpea in a 17-year-old female: a case report. J Med Case Rep 9:186.


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 29.10.2020