Synonym(s)
Ebbi Swartzman phenomenon; Sanarelli-Shwartzman reaction; Shwartzman Phenomenon; Shwartzman reaction; Shwartzman-Sanarelli reaction
HistoryThis section has been translated automatically.
Sanarelli, 1924 (first description of the generalized form); Shwartzman, 1928 (first description of the localized form)
DefinitionThis section has been translated automatically.
Shock and adrenal cortex necrosis after 2 injections of Gram-negative bacteria within 24 hours.
EtiopathogenesisThis section has been translated automatically.
Lipopolysaccharides ( LPS of the bacterial membrane) lead to the activation of monocytes and release of tumor necrosis factors and interleukin-1.
LiteratureThis section has been translated automatically.
- Ramirez-Hernandez C et al (2004) Mast cell density during initiation and progression of the local Shwartzman reaction. Inflamm Res 53: 107-110
- Riemekasten G et al (2002) Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation. Lupus 11: 204-207
- Shwartzman G (1928) A new phenomenon of local skin reactivity to B. typhosus culture filtrate. Proc Soc Exp Biol Med 25: 560-561
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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer