Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 02.12.2023

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AIADK; CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; MSPC; NAC; NALP1; NLR family; NLR family pyrin domain containing 1; PP1044; pyrin domain containing 1; SLEV1; VAMAS1

General information
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Like other NLRPs, NLRP1 is one of the key mediators of programmed cell death. The NLRP1 protein interacts with caspase 1 and to a lesser extent with caspase 9. The interleukins interleukin-1β and interleukin-18 as well as a lytic form of cell death(pyroptosis/necroptosis) are processed via this activation pathway. NLRP1 is activated by numerous microbial stimuli (Bacillus anthracis lethal toxin, Toxoplasma gondii, muramyl dipeptides, viral proteins (?).

Polymorphisms in the NLRP1 gene are associated with a familial form of vitiligo .

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  2. D'Osualdo A et al.(2012) NLRP1, a regulator of innate immunity associated with vitiligo. Pigment Cell Melanoma Res 25:5-8.
  3. Yang CA et al(2015) Inflammasomes and human autoimmunity: A comprehensive review. J Autoimmune 61:1-8.


Last updated on: 02.12.2023