Molgramostim
Synonym(s)
GM-CSF
Definition
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Cytokine, granulocyte-macrophage colony stimulating factor.
Pharmacodynamics (Effect)
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Proliferation and differentiation of progenitor cells of granulopoiesis, monocytes and macrophages, eosinophils, erythropoiesis and megakaryopoiesis Increase of the production rate of neutrophils by 50%, extension of the circulation half-life of neutrophils from 4 to 48 hours.
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Indication
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Severe neutropenia in patients treated with myelotoxic chemotherapeutic agents.
Dosage and method of use
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5-10 μg/kg bw/day s.c.
Notice!
Therapy only under supervision of oncologically experienced doctors!
Undesirable effects
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Fever, nausea, vomiting, diarrhea, dyspnea, rigor, allergic reactions, fatigue, anorexia, bone pain, asthenia, non-specific thoracic pain, stomatitis, headache, sweating, pruritus, dizziness, peripheral edema, paraesthesia, myalgias.
Interactions
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Decrease of the serum albumin level, possibly dose adjustment of drugs with high binding affinity to serum albumin.
Contraindication
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Pregnancy, lactation, basic malignant myeloid disease (myelodysplastic syndrome, AML).
Preparations
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Leucomax (available through the international pharmacy).
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Prof. Dr. med. Peter Altmeyer