Synonym(s)
Leukotriene C4 synthase; LTC4S
DefinitionThis section has been translated automatically.
Leukotriene C4 synthase is an enzyme that in humans is encoded by the LTC4S gene on chromosome 5q35.
The protein encoded by this gene is an enzyme that (selectively) enzymatically conjugates leukotriene A4 and glutathione to leukotriene C4 .
The enzyme is expressed by a limited number of cells, such as eosinophilic granulocytes, mast cells, basophilic granulocytes and monocytes/macrophages. Various leukemia cell lines such as KG-1 cells and THP-1 cells can produce this enzyme.
Furthermore, leukotriene C4 synthase is detectable in platelets.
LiteratureThis section has been translated automatically.
- Kazani S et al (2014) LTC4 synthase polymorphism modified efficacy of botanical seed oil combination in asthma. Knightplus 3:661.
- Roos C et al (2004) Abnormal LTC4 synthase RNA degradation in neutrophils from CML patients. Br J Haematol 124:739-745.
- Sayers I et al (2003) Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma. Chest 58:417-424.
- Zhang Y et al (2012) The -444A/C polymorphism in the LTC4S gene and the risk of asthma: a meta-analysis. Arch Med Res 43:444-450.
Prof. Dr. med. Peter Altmeyer