Latex allergens

Definition
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Barre A et al (2009) Mapping of IgE-binding epitopes on the major latex allergen Hev b 2 and the cross-reacting 1,3beta-glucanase fruit allergens as a molecular basis for the latex-fruit syndrome. Mol immunol 46:1595-1604.
Berthelot K et al (2014) Hevea brasiliensis REF (Hev b 1) and SRPP (Hev b 3): An overview on rubber particle proteins. Biochemistry 106:1-9.
Galicia C et al (2015) Impact of the vulcanization process on the structural characteristics and IgE recognition of two allergens, Hev b 2 and Hev b 6.02, extracted from latex surgical gloves. Mol immunol 65: 250-258.

Hev b 1 (Rubber Elongation Factor): late-type particle-bound protein involved in rubber synthesis.
Hev b 1 and Hev b 6: for both proteins, a high degree (>70%) of sensitization is observed in health care workers.
Hev b 1, Hev b 3, Hev b 5: for these proteins, a high degree of sensitization is observed in spina bifida patients.
Hev b 7 (patatin-like protein) shows sequence homologies with the patatins of the nightshade family (Solanaceae - potatoes and tomatoes are included).
Hev b 6 (prohevein): is responsible for a cross-reaction between latex and the ascarola cherry (see Latex Fruit Syndrome)
Hev b 8 (latex profilin): is responsible for a cross-reaction between latex and sweet chestnut (see latex-fruit syndrome)

Barre A et al (2009) Mapping of IgE-binding epitopes on the major latex allergen Hev b 2 and the cross-reacting 1,3beta-glucanase fruit allergens as a molecular basis for the latex-fruit syndrome. Mol immunol 46:1595-1604.
Berthelot K et al (2014) Hevea brasiliensis REF (Hev b 1) and SRPP (Hev b 3): An overview on rubber particle proteins. Biochemistry 106:1-9.
Galicia C et al (2015) Impact of the vulcanization process on the structural characteristics and IgE recognition of two allergens, Hev b 2 and Hev b 6.02, extracted from latex surgical gloves. Mol immunol 65: 250-258.
Raulf M et al (2015) Latex allergen: Sources of sensitization and single allergens. In: Kleine-Tebbe J et al. Hrsg Molecular allergy diagnostics. Springer Verlag Berlin-Heidelberg S 339-346.