DefinitionThis section has been translated automatically.
Glycoprotein IIb/IIIa receptors are altered in their conformation by stimulators such as thrombin, ADP, thrombaxane, collagen, platelet activating factors and adrenaline and express high-affinity fibrinogen binding sites. This is where the blocking drugs attack. GPIIb/IIIa antagonists used in the clinic are monoclonal antibodies.
Currently on the market are:
- Abcimiximab
- Eptifibatide
- Tirofiban
LiteratureThis section has been translated automatically.
- HA Neumann (2014) The coagulation system. ABW-Scientific Publisher GmbH Berlin
Prof. Dr. med. Peter Altmeyer