Endotoxin shock R57.8

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Shock symptoms, caused by an infection with endotoxin-containing bacteria. Endotoxins are lipopolysaccharides (LPS) in the outer cell membrane of various Gram-negative bacteria.

Etiopathogenesis
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Interaction with monocytic cells in particular leads to the activation and release of interleukin-1, interleukin-6 and especially tumor necrosis factor-α. This leads to an increase in temperature, collagenase production, histamine release, macrophage activation, activation of endothelial cells.

Clinical features
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Fever, leukopenia, drop in blood pressure, intravascular coagulation.

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020