Contact dermatitis lymphomatoids L23.3.; L23.4; L23.5

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Lymphocytic contact dermatitis; Lymphomatoid contact dermatitis; Lymphomatoid photocontact dermatitis

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Rare pseudolymphoma localized at the contact site by a "contact allergic" also"photocontact allergic" also "aerogenic" mechanism with clinical and histological criteria and aspects of contact allergic dermatitis and cutaneous T-cell lymphoma.

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Epidemiological data are not available. The disease is extremely rare. m>w

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Special contact allergic reaction to different types of food allergens.

The following allergens are listed in the literature: methylisothiazolinone , benzydamine hydrochloride, minoxidil, metals such as gold, cobalt, nickel and 4-tert-butylphenol.

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40-60 years; the average in a larger study (n= 23 patients) was 58.5 years.

Clinical features
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The clinical picture is similar to contact allergic eczema and is therefore limited to the site of application.

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Histologically there are characteristics of a Mycosis fungoides.

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Lymphomatoid tissue reactions, which describe tissue reactions that have a "lymphoma-like aspect", belong to the category of "pseudo-lymphomas". Pseudolymphomas after systemic medication are described in a large number of drugs (see below lymphocytic drug reactions) and are characterized by a very different clinical morphology.

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  1. Alvarez-Garrido H et al (2010) Lymphomatoid photocontact dermatitis to benzydamine hydrochloride. Contact dermatitis 62: 117-119
  2. Conde-Taboada A et al (2007) Lymphomatoid contact dermatitis induced by gold earrings. Contact Dermatitis 56: 179-181
  3. Evans AV et al (2003) Lymphomatoid contact dermatitis to para-tertyl-butyl phenol resin. Clin Exp Dermatol 28: 272-273.
  4. Ezzedine K etg al. (2007) Lymphomatoid contact dermatitis to an exotic wood: a very harmful toilet seat. Contact Dermatitis 57:128-130
  5. García-Rodiño S et al (2015) Persisting allergic patch test reaction to minoxidil manifested as cutaneouslymphoid dermatitis 72:413-416.
  6. Hession MT et al (2010) Lymphomatoid allergic contact dermatitis mimicking cutaneous T cell lymphoma. Dermatitis 21:220
  7. Houck HE et al (1997) Lymphomatoid contact dermatitis caused bynickel. Am J Contact Dermat 8: 175-176
  8. Knackstedt TJ etg al.(2015) T cell lymphomatoid contact dermatitis: a challenging case and review of the literature. Contact Dermatitis 72: 65-74
  9. Marlière V et al (1998) Lymphomatoid contact dermatitis caused byisopropyl-diphenylenediamine: two cases. J Allergy Clin Immunol 102:152-153
  10. Narganes LM et al (2012) Lymphomatoid dermatitis caused by contact with textile dyes. Contact Dermatitis 68: 62-64
  11. Orbaneja JG et al (1976) Lymphomatoid contact dermatitis: a syndrome produced by epicutaneous hypersensitivity with clinical features and a histopathologic picture similar to that of mycosis fungoides. Contact dermatitis 2:139-143
  12. Schena D et al (1995) Lymphomatoid-like contact dermatitis from cobalt naphthenate. Contact dermatitis 33:197-198
  13. Van Steenkiste E et al (2015) Airborne-induced lymphomatoid contact dermatitis caused by methylisothiazolinone. Contact Dermatitis 72: 237-240


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 29.10.2020