Coeruloplasmin

A copper oxidizing enzyme which is bound in the liver and migrates in the alpha2-globulin fraction in serum electrophoresis.

Its functions are:

• Binding of copper (Cu) in plasma and Cu transport n tissue.
• Influence on the redox status of plasma, antioxidant effect.
• Acute phase protein in inflammation
• Regulation of the ion ion status of iron

Standard values: In serum the standard value is between 20 and 60 mg/dl or 0,94 and 3,75 µmol/l

Pathologically increased in: neoplasia, pregnancy, cholestasis, acute inflammation. In serum electrophoresis there is an increase in the alpha2-globulin fraction.

Note: The use of oral contraceptives leads to a dose-dependent 20-30% increase in serum Cp concentration.

Pathologically decreased: liver cirrhosis, nephrotic syndrome, Wilson's disease