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Essential interactions of H2-antagonists
Acenocoumarol |
Bleeding tendency ↑ |
Barbiturates |
Barbiturate levels ↑ |
Captopril |
Neuropathy ↑ |
Carbamazepine |
Carbamazepine levels ↑ |
Carmustin |
Carmustine toxicity ↑, myelosuppression ↑ |
Chlordiazepoxide |
Chlordiazepoxide levels ↑ |
Chlorpromazine |
Tiredness ↑ |
Clomethiazole |
Clomethiazole levels ↑ |
Digitoxin |
Digitoxin toxicity ↑ |
Diltiazem |
Diltiazem toxicity ↑ |
Iron |
Iron Mirrors ↓ |
Erythromycin |
Erythromycin toxicity ↑, hearing impairment ↑ |
Halofrantin |
Halofrantin bioavailability ↓, avoid combination |
Hydromorphone |
Hydromorphone mirrors ↑ |
Isradipin |
Isradipine levels ↑, RR drop, halve the Isradipine dose |
Itraconazole |
Itraconazole level ↓, intake 2 hours apart |
Ketoconazole |
Ketoconazole levels ↓ |
Labetalol |
Labetalol mirrors ↑ |
Levomethadone |
Levomethadone levels ↑ |
Lidocaine IV. |
Lidocaine levels ↑, halve lidocaine dose |
Magnesium Antacids |
H2-antagonist mirror ↓, to be taken 2 hours apart |
Mebendazole |
Mebendazole level ↑ |
Metformin |
Metformin-Spiegel↑, Lactate Acidosis |
Metoclopramide |
H2-antagonist mirror ↓, to be taken 2 hours apart |
Metoprolol |
Metoprolol levels ↑, bradycardia |
Nifedipine |
Nifedipine levels ↑, RR waste |
Nicotine abuse |
H2-antagonist effect ↓ |
Opioid analgesics |
Opioid toxicity ↑, seizures, confusion, respiratory arrest |
Phenytoin |
Phenytoin levels ↑ |
Procainamide |
Procainamide level ↑, excitation conduction disorders |
Propanolol |
Propanolol levels ↑, bradycardia |
Rifabutin |
Rifabutin levels ↑ |
Sulfonylurea antidiabetics |
antidiabetic effect ↑ |
Terbinafine |
Terbinafine levels ↑ |
Tetracyclines |
Tetracycline effect ↓ |
Theophylline |
Theophylline levels ↑ |
Valproic acid |
Valproic acid level ↑ |
Warfarin |
Bleeding tendency ↑ |
Zidovudine |
Zidovudine toxicity ↑ |
Overview of the most important H2-antagonists and their dosage
Active substance |
Dosage |
Preparation |
Cimetidine |
400 mg/day p.o. |
Tagamet |
Famotidine |
20 mg/day p.o. in the evening |
Pepdul |
Nizatadine |
200 mg/day p.o. in the evening |
Nizax |
Ranitidine |
300 mg/day p.o. in the evening |
Sostril, Zantic |