DefinitionThis section has been translated automatically.
6-keto-prostaglandin F1alpha is the physiologically active and stable metabolite of prostaglandin GI2 (PGI2) and can be detected in very small amounts in all mammals. In human plasma, concentrations of less than 50 pg/ml are measured.
A delayed increase of 6-keto-PGF1 alpha is detected in animals with septic shock. 6-keto-prostaglandin F1a plasma levels may increase in patients with epidemic hemorrhagic fever. Elevated levels are also found in obstructive suppurative cholangitis and in patients with gynecological carcinomas.
LiteratureThis section has been translated automatically.
- Desai UA et al (2002) Determination of prostacyclin in plasma through a bioluminescent immunoassay for 6-keto-prostaglandin F1alpha: implication of dosage in patients with primary pulmonary hypertension. Anal Chem 74:3892-3898.
- Greaves M et al (1982) Plasma 6-keto-prostaglandin F1alpha: fact or fiction. Thromb Res 26:145-157.