Thrombophlebitis saltansI82.1

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 04.11.2022

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Synonym(s)

Phlebitis migrans; Phlebitis saltans; Thrombophlebitis saltans; Trousseau`s syndrome; Trousseau Syndrome

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HistoryThis section has been translated automatically.

Armand Trousseau, 1865

DefinitionThis section has been translated automatically.

Very rare, strand-like "jumping" superficial thrombophlebitis (see also Mondor's disease), which, among other things, is also considered a monitoring early symptom of an occult visceral tumor (e.g., pancreatic carcinoma - C25.8) (facultative paraneoplastic syndrome). Unlike varicophlebitis, it also affects primary non-varicose veins.

EtiopathogenesisThis section has been translated automatically.

Probably hypercoagulatory (allergic-hyperergic), thrombotic vascular reaction.

Most commonly, this segmental inflammatory phlebitis is observed in the setting of thrombangitis obliterans. It may also occur in isolation. Other triggers may include:

  • Chronic bacterial focal infections
  • Carcinomas (especially pancreatic carcinoma; also carcinomas of the lung and prostate; tumors can express cysteine proteinases that directly activate factor X and thus increase thrombin production ) - Note: this constellation seems to be rather rare!
  • Behçet's disease
  • Malignant lymphogranulomatosis and leukoses.

ManifestationThis section has been translated automatically.

Occurring mainly in men. Thrombophlebitis saltans is a partial symptom of thrombangiitis obliterans.

LocalizationThis section has been translated automatically.

Especially extensor sides of the lower extremities are affected.

Clinical featuresThis section has been translated automatically.

A "jumping", acute, stranded, well palpable, painful thrombophlebitis is observed, running in phases over different vein sections; the phlebitic strands are 4.0-10.0 cm long. Short-term temperature increases during the thrust are possible. The changes heal spontaneously after 2-3 weeks with slight hyperpigmentation.

HistologyThis section has been translated automatically.

Thrombotic venous occlusion. Perivenous infiltration with histiocytes and giant cells.

Differential diagnosisThis section has been translated automatically.

Panniculitis.

TherapyThis section has been translated automatically.

Cause search and remediation, smoking ban, tumor exclusion.

External therapyThis section has been translated automatically.

Possibly compression bandages, heparin ointments.

Internal therapyThis section has been translated automatically.

anti-inflammatory drugs (e.g. acetylsalicylic acid 2-3 g/day), possibly corticoids 50-100 mg/day)

Progression/forecastThis section has been translated automatically.

Healing of the individual relapses in 2-3 weeks, leaving behind hyperpigmentation.

Note(s)This section has been translated automatically.

A special form of thrombophlebitis saltans is Mondor's disease, which affects the veins on the lateral wall of the throax.

LiteratureThis section has been translated automatically.

  1. Koushk-Jalali B et al (2020) Thrombophlebitis migrans. Dtsch Ärztebl Int 117: 125
  2. Varki A (2007)Trousseau's syndrome: multiple definitions and multiple mechanisms. Blood 110:1723-1729

Authors

Last updated on: 04.11.2022

Author: Prof. Dr. med. Peter Altmeyer

Editor: Dr. med. Bijan Koushk Jalali