Methylated flavone derivative contained in e.g. Orthosiphon stamineus (see also eupatorin, sinensitin). In experimental approaches, scutellarein has been shown to have antiproliferative, neuroprotective and anti-angiogenetic effects. The anti-angiogenetic effect is induced by a modulation of the growth factor VEGF.
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Scutellarein
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- Cheng CY et al (2014) Inhibitory effects of scutellarein on proliferation of human lung cancer A549 cells through ERK and NFκB mediated by the EGFR pathway. Chin J Physiol 57:182-187.
- Shi X et al (2015) Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo. Int J Mol Med 35:31-38.
- Tang H et al. (2014) Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia-reperfusion in rats. Pharmacol Biochem Behav 118:51-59.
- Thirusangu P et al (2017) .scutellarein antagonizes the tumorigenesis by modulating cytokines VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2017.01.067.