Radix alkannae

Authors:Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

Alcana root; Dyer's weed root; Radix Anchusae tinctoriae

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DefinitionThis section has been translated automatically.

Extract from the root Alkanna tuberculata, the make-up root.

IngredientsThis section has been translated automatically.

Alkannin, alkannarot, anchusin, alkannic acid, tannins, pyrrolizidine alkaloids

Spectrum of actionThis section has been translated automatically.

In experimental studies, alkannin and its esters show an antibiotic-like effect. Extracts of the alkanna root also have an antiphlogistic effect and promote wound healing.

Field of application/useThis section has been translated automatically.

(there are no monographs of the various Commissions before e.g. Commission E): Chronic wounds (this indication was already known in ancient times); recently alkannin is also used for the treatment of varicose veins. The effectiveness is not sufficiently proven.

LiteratureThis section has been translated automatically.

  1. Huu Tung N et al.(2013) Naphthoquinone components from Alkanna tinctoria (L.) Exchange show significant antiproliferative effects on human colorectal cancer cells. Phytother Res 27:66-70.
  2. Karayannopoulou M et al.(2011) Evaluation of the effectiveness of an ointment based on Alkannins/Shikonins on second intention wound healing in the dog. Can J Vet Res 75:42-48.
  3. Papageorgiou VP et al.(2008) Alkannins and shikonins: a new class of wound healing agents. Curr Med Chem 15:3248-3267.
  4. Wang Y et al(2016) Suppressive effect of β,β-dimethylacryloyl alkannin on activated dendritic cells in psoriasis by the TLR7/8 pathway. Int Immunopharmacol 40:410-418.
  5. Wang R et al (2014) Synthesis and evaluation of novel alkannin and shikonin oxime derivatives as potent antitumor agents. Bioorg Med Chem Lett 24:4304-4307.

Authors

Last updated on: 29.10.2020

Authors: Prof. Dr. med. Peter AltmeyerProf. Dr. med. Martina Bacharach-Buhles