Isolated anonychy-onycholysisL60.8
Synonym(s)
DefinitionThis section has been translated automatically.
Although nails appear normal at birth in this autosomal recessive inherited syndrome, dystrophic changes in the nails develop during the first decade of life, leading to onycholysis of the fingernails and anonymity of the toenails. This disorder is called non-syndromic congenital nail disorder-9 (NDNC9).
EtiopathogenesisThis section has been translated automatically.
This is based on a mutation of a gene localized on chromosome 17q25.1-17q25.3 (Rafiq MA et al. 2004).
Clinical featuresThis section has been translated automatically.
Rafiq et al. (2004) reported on a consanguine Pakistani family in which a form of hereditary nail dysplasia was detected over 6 generations. The affected persons had normal nails at birth. The onychodystrophy developed at the age of 7 or 8 years and led to an anonymity of the toenails as well as to onycholysis of the fingernails. Further anomalies of the ectodermal appendages were not observed in any of the affected individuals.
LiteratureThis section has been translated automatically.
- Rafiq MA et al (2004) Localization of a novel locus for hereditary nail dysplasia to chromosomes 17q25.1-17q25.3 Clin Genet 66: 73-78
- Zaias N et al (2015) Finger and toenail onycholysis. J Eur Acad Dermatol Venereol 29:848-853.