Frangulae cortex
Synonym(s)
DefinitionThis section has been translated automatically.
Medicinally used dried bark of the branches and younger trunks of Franula alnus the fine-leaved alder, monogrpahized in Ph.Eur.2.
IngredientsThis section has been translated automatically.
Efficacy determining ingredients: numerous hydroxyanthracene glycosides, especially of the aloe emodin type, as well as glycosides of emodin (of which 80-90% are C-glycosides of the aloe type, so-called cascarosides); furthermore frangulin A and frangulin B and saponins, more rarely also bitter substances andtannins.
EffectsThis section has been translated automatically.
Laxative, anti-absorptive.
Field of application/useThis section has been translated automatically.
Indication: chronic constipation,
DosageThis section has been translated automatically.
0.5-2.0g as 10% decoction 20.0g. Duration of the intake 1-2 weeks.
The fresh drug has emetic effect (fresh bark contains anthrones and dianthrones which are no longer present in deposited bark).
ContraindicationThis section has been translated automatically.
Contraindications: Ileus, acute inflammatory bowel disease, unclear abdominal pain
Note(s)This section has been translated automatically.
Not for children <12 years
LiteratureThis section has been translated automatically.
- Brkanac SR et al (2015) Toxicity and antioxidant capacity of Frangula alnus Mill. bark and its activeemodin. Regul Toxicol Pharmacol 73:923-929.
- Demuth G et al,(1978) Investigations on anthraquinonglycosides of Rhamnus species, V Emodin-8-O-beta-gentiobioside,e a new O-glycoside from Rhamnus frangula. Planta Med 33:53-56.
- Koyama J et al (2001) Inhibitory effects of anthraquinones and bianthraquinones on Epstein-Barr virus activation. Cancer Lett 170:15-18.
- Sadowska B et al (2014) Vaccinium myrtillus leaves and Frangula alnus bark derived extracts as potential antistaphylococcal agents. Acta Biochim Pol 61:163-169.