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Cimicifugae racemosae rhizoma
Synonym(s)
DefinitionThis section has been translated automatically.
Extract from the root system (rhizome+roots) of black co hosh (Cimicifuga racemosa), which is used for medicinal purposes. The root extracts of black cohosh, also known as women's root, were already used in the 18th century to treat gynecological diseases.
HMPC monograph: Well-established use: Menopausal symptoms, hot flushes, excessive sweating.
Approved, supported by clinical data: Psychological and neurovegetative symptoms during the menopause.
ESCOP monograph: Climacteric symptoms such as hot flushes, profuse sweating, sleep disorders, nervous irritability
Commission e-monograph: Premenstrual, dysmenorrheal, climacteric-related neurovegetative symptoms.
Pharmacodynamics (Effect)This section has been translated automatically.
The active ingredients of the root extracts are actein, a glycoside with a hypotensive effect, as well as the terpene derivative (tetracyclic triterpene), cymogonol monoxyloside (cimicifugoside), cimiracemoside and cimegenol-3-O-alpha-L-arabinoside = typical lead substance for Cimicifuga racemosa). Furthermore, the root extract contains tannins, salicylic and gallic acid as well as various alkaloids (cytisine, cytisine, cytosine). Alkaloids (cytisine) are also contained in the root extract.
The use of ready-made preparations is strongly recommended, not tea infusions!
Spectrum of actionThis section has been translated automatically.
The extract has a weak estrogenic effect; it also has an anti-inflammatory, antipyretic and sedative effect.
The ingredients bind to estrogen receptors (competition with estradiol and hence the name "phyto-SERMs").
IndicationThis section has been translated automatically.
Limited indicationThis section has been translated automatically.
Breast cancer only after consultation with a doctor, liver dysfunction, vaginal bleeding when taking
Pregnancy/nursing periodThis section has been translated automatically.
Do not use during pregnancy or while breastfeeding.
Undesirable effectsThis section has been translated automatically.
Liver toxicity, allergic skin reactions(urticaria, itching, exanthema), facial edema, peripheral edema, gastrointestinal disorders: dyspepsia, diarrhea.
ContraindicationThis section has been translated automatically.
Combination with estrogens, pregnancy and breastfeeding in the absence of data; allergy to one of the ingredients
PreparationsThis section has been translated automatically.
Femikliman® uno film-coated tablets (ED 6.5mg), 1-0-0
Feminon C® hard capsules (ED 6.5mg), 1-0-0
Klimadybin uno ® Flem tablets (ED 6.5mg), 1-0-0
Remifemin tablets (ED 2.5mg), 1-0-1
Combination preparation:
- Black cohosh +
- St. John's wort
Remifemin plus® film-coated tablets, 1(2)-0-1(2) approved preparation since 01.08.2018